Ketamine Nasal Spray Treatment (Esketamine) Clinic | Tulsa, Oklahoma

What is Nasal Ketamine Treatment?

Nasal ketamine treatment, commonly known by the brand name Spravato (esketamine), is an FDA-approved treatment derived from ketamine, a medication that has been used safely in medical settings for decades. Administered as a nasal spray in a clinical setting, it works differently from traditional antidepressants by targeting the brain’s glutamate system, which plays a key role in mood regulation and pain processing. Results can often be felt more quickly than with conventional medications.

What Conditions Does Ketamine Nasal Spray Treat?

Ketamine nasal spray may be an appropriate treatment option for patients with:

• Treatment-resistant depression (depression that has not responded to two or more antidepressant medications)
• Major depressive disorder (MDD) with acute suicidal ideation or behavior
• Chronic pain conditions
• Anxiety associated with depression

When you schedule an appointment with Memorial Pain Clinic, board-certified pain management physician Dr. Leslie Chan will evaluate your medical history and symptoms to determine whether ketamine nasal treatment is a suitable option for your specific needs.

Is Ketamine Nasal Spray Safe?

When administered in a supervised clinical setting by a qualified physician, ketamine nasal spray is considered safe for appropriate candidates. Our Tulsa, OK medication management team at Memorial Pain Clinic carefully screens each patient prior to treatment and monitors them throughout every session.

Potential side effects, including temporary dizziness, nausea, or dissociation, are generally mild and resolve shortly after the session ends. Dr. Chan will review all risks and benefits with you in detail during your initial consultation.

How Does Ketamine Nasal Spray Work?

Unlike traditional antidepressants that target serotonin or dopamine, ketamine works by blocking NMDA receptors in the brain and stimulating the growth of new neural connections. This process (known as neuroplasticity) is believed to be a key reason why ketamine can produce rapid improvements in mood and pain levels. Patients often notice changes within hours or days, rather than the weeks or months typically required for conventional antidepressants.

What to Expect During Treatment

Ketamine nasal spray is administered in our clinic under the supervision of Dr. Chan. Because the medication can cause temporary dissociative effects such as dizziness, altered perception, or mild sedation, patients are monitored for a period of time following each session before being cleared to leave. You will need a responsible adult to drive you home after each appointment.

Treatment sessions are typically scheduled twice a week during an initial induction period, followed by a maintenance schedule based on your response.

How Many Treatments Are Needed?

The number of treatments varies by individual. Most patients begin with an induction phase consisting of multiple sessions over several weeks, followed by ongoing maintenance treatments as needed. We will monitor your response closely and adjust your treatment plan accordingly to achieve the best possible outcome.

How Long Do the Effects of Ketamine Nasal Spray Last?

Many patients experience relief that lasts days to weeks following each treatment session. With a consistent maintenance schedule, the benefits can be sustained over the long term. Because individual responses vary, Dr. Chan will work with you to find the right treatment frequency for lasting results.

How Much Does Ketamine Nasal Spray Treatment Cost?

The cost of ketamine nasal spray treatment depends on your insurance plan and the number of sessions required. Spravato (esketamine) is FDA-approved and covered by many insurance plans when specific clinical criteria are met.

Memorial Pain Clinic accepts most major insurances. Call our office at (918) 200-9944 to discuss your coverage and find out if you qualify.

Is Ketamine Nasal Spray Treatment Right for You?

Ketamine nasal spray treatment is not for everyone, but for the right patient, it can be life-changing. If you have struggled with treatment-resistant depression or chronic pain and are looking for a new approach, we encourage you to schedule a consultation with Memorial Pain Clinic to explore your options.

Schedule Your Consultation at Memorial Pain Clinic Today

Memorial Pain Clinic in Tulsa, Oklahoma is proud to offer cutting-edge treatments like ketamine nasal spray therapy to help patients reclaim their quality of life. Dr. Leslie Chan, MD is board-certified in pain management and committed to providing personalized, compassionate care.

We accept most insurances, including BCBS, Community Care, and MVA. Give us a call at (918) 200-9944 or reach out online to schedule your consultation today.